Immune Inhibitory Receptors

DOI Web Site 被引用文献35件
  • Jeffrey V. Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10021, USA.
  • Lewis L. Lanier
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA.

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<jats:p>With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the pairing of activation and inhibition is necessary to initiate, amplify, and then terminate immune responses. In some cases, the activating and inhibitory receptors recognize similar ligands, and the net outcome is determined by the relative strength of these opposing signals. The importance of this modulation is demonstrated by the sometimes fatal autoimmune disorders observed in mice with targeted disruption of inhibitory receptors. The significance of these receptors is further evidenced by the conservation of immunoreceptor tyrosine-based inhibitory motifs during their evolution.</jats:p>

収録刊行物

  • Science

    Science 290 (5489), 84-89, 2000-10-06

    American Association for the Advancement of Science (AAAS)

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