Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt
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            Cells

Gérard Eberl, Dan R. Littman

doi:10.1126/science.1096472

Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt <sup>+</sup> Cells

DOI Web Site 被引用文献24件

Gérard Eberl

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Dan R. Littman

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

抄録

<jats:p> Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to differentiate from local precursors rather than from thymocytes. We show here that IELs expressingthe αβ T cell receptor are derived from precursors that express RORγt, an orphan nuclear hormone receptor detected only in immature CD4 <jats:sup>+</jats:sup> CD8 <jats:sup>+</jats:sup> thymocytes, fetal lymphoid tissue–inducer (LTi) cells, and LTi-like cells in cryptopatches within the adult intestinal lamina propria. Using cell fate mapping, we found that all intestinal αβ T cells are progeny of CD4 <jats:sup>+</jats:sup> CD8 <jats:sup>+</jats:sup> thymocytes, indicatingthat the adult intestine is not a significant site for αβ T cell development. Our results suggest that intestinal RORγt <jats:sup>+</jats:sup> cells are local organizers of mucosal lymphoid tissue. </jats:p>