Auxiliary Subunits Assist AMPA-Type Glutamate Receptors

• Roger A. Nicoll

  Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA.

• Susumu Tomita

  Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA.

• David S. Bredt

  Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA.

Abstract

Glutamate, the major excitatory neurotransmitter in the brain, acts primarily on two types of ionotropic receptors: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and N -methyl- d -aspartate (NMDA) receptors. Work over the past decade indicates that regulated changes in the number of synaptic AMPA receptors may serve as a mechanism for information storage. Recent studies demonstrate that a family of small transmembrane AMPA receptor regulatory proteins (TARPs) controls both AMPA receptor trafficking and channel gating. TARPs provide the first example of auxiliary subunits of ionotropic receptors. Here we review the pivotal role that TARPs play in the life cycle of AMPA receptors.

Journal

• Science

  Science 311 (5765), 1253-1256, 2006-03-03

  American Association for the Advancement of Science (AAAS)

Keywords

• Multidisciplinary

Details

• CRID: 1360292618741460864
• NII Article ID: 30020394321
• DOI: 10.1126/science.1123339
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1123339
• Data Source:
  • Crossref
  • CiNii Articles