Coupling Between Neuronal Firing, Field Potentials, and fMRI in Human Auditory Cortex

DOI Web Site 被引用文献7件
  • Roy Mukamel
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Hagar Gelbard
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Amos Arieli
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Uri Hasson
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Itzhak Fried
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Rafael Malach
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.

抄録

<jats:p> Functional magnetic resonance imaging (fMRI) is an important tool for investigating human brain function, but the relationship between the hemodynamically based fMRI signals in the human brain and the underlying neuronal activity is unclear. We recorded single unit activity and local field potentials in auditory cortex of two neurosurgical patients and compared them with the fMRI signals of 11 healthy subjects during presentation of an identical movie segment. The predicted fMRI signals derived from single units and the measured fMRI signals from auditory cortex showed a highly significant correlation ( <jats:italic>r</jats:italic> = 0.75, <jats:italic>P</jats:italic> < 10 <jats:sup>–47</jats:sup> ). Thus, fMRI signals can provide a reliable measure of the firing rate of human cortical neurons. </jats:p>

収録刊行物

  • Science

    Science 309 (5736), 951-954, 2005-08-05

    American Association for the Advancement of Science (AAAS)

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