Decarboxylase Inhibition and Blood Pressure Reduction by α-Methyl-3,4-Dihydroxy-DL-phenylalanine

• J. A. Oates

  National Heart Institute, Bethesda, Maryland

• L. Gillespie

  National Heart Institute, Bethesda, Maryland

• S. Udenfriend

  National Heart Institute, Bethesda, Maryland

• A. Sjoerdsma

  National Heart Institute, Bethesda, Maryland

抄録

α-Methyl-3,4-dihydroxy-DL-phenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.

収録刊行物

• Science

  Science 131 (3417), 1890-1891, 1960-06-24

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360579818379370112
• NII論文ID: 30020476026
• DOI: 10.1126/science.131.3417.1890
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.131.3417.1890
• データソース種別:
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  • CiNii Articles