Induction of Drug-Metabolizing Enzymes in Liver Microsomes of Mice and Rats by Softwood Bedding

DOI Web Site 被引用文献6件
  • Elliot S. Vesell
    Section on Pharmacogenetics, Laboratory of Chemical Pharmacology, National Institutes of Health, Bethesda, Maryland 20014

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<jats:p>Induction of three drug-metabolizing enzymes occurred in liver microsomes of mice and rats kept on softwood bedding of either red cedar, white pine, or ponderosa pine. This induction was reversed when animals were placed on hardwood bedding composed of a mixture of beech, birch, and maple. Differences in the capacity of various beddings to induce may partially explain divergent results of studies on drug-metabolizing enzymes. The presence of such inducing substances in the environment may influence the pharmacologic responsiveness of animals to a wide variety of drugs.</jats:p>

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  • Science

    Science 157 (3792), 1057-1058, 1967-09

    American Association for the Advancement of Science (AAAS)

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