Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement

DOI Web Site 被引用文献6件
  • Hyun S. Shin
    Department of Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • Ralph Snyderman
    Laboratory of Microbiology, National Institute of Dental Research, Bethesda, Maryland
  • Eileen Friedman
    Department of Microbiology, Johns Hopkins University School of Medicine
  • Alice Mellors
    Department of Microbiology, Johns Hopkins University School of Medicine
  • Manfred M. Mayer
    Department of Microbiology, Johns Hopkins University School of Medicine

抄録

<jats:p> The fifth component of guinea pig complement, with a sedimentation coefficient 7.8 <jats:italic>S</jats:italic> , is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4 <jats:italic>S</jats:italic> and 1.5 <jats:italic>S</jats:italic> . The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum. </jats:p>

収録刊行物

  • Science

    Science 162 (3851), 361-363, 1968-10-18

    American Association for the Advancement of Science (AAAS)

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