Genetic Aspects of Increase in Rat Liver Aldehyde Dehydrogenase Induced by Phenobarbital

• Richard A. Deitrich

  Department of Pharmacology, University of Colorado Medical Center, Denver 80220

抄録

In the supernatant fraction of homogenized rat liver, the activity of aldehyde dehydrogenase that is dependent on nicotinamide adenine dinucleotide (E.C. 1.2.1.3) is increased up to tenfold after administration of phenobarbital for 3 days. The effect is genetically controlled and is inherited as an autosomal dominant characteristic. The mechanism is apparently unrelated to other drug-induced increases in enzyme activity such as that which occurs in the hepatic microsomal systems for drug metabolism.

収録刊行物

• Science

  Science 173 (3994), 334-336, 1971-07-23

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363388843353689728
• NII論文ID: 30020500141
• DOI: 10.1126/science.173.3994.334
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.173.3994.334
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