Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro

DOI Web Site 被引用文献8件
  • G. G. Glenner
    National Institutes of Health, Bethesda, Maryland 20014
  • D. Ein
    National Institutes of Health, Bethesda, Maryland 20014
  • E. D. Eanes
    National Institutes of Health, Bethesda, Maryland 20014
  • H. A. Bladen
    National Institutes of Health, Bethesda, Maryland 20014
  • W. Terry
    National Institutes of Health, Bethesda, Maryland 20014
  • D. L. Page
    National Institutes of Health, Bethesda, Maryland 20014

抄録

<jats:p>"Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, β-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested.</jats:p>

収録刊行物

  • Science

    Science 174 (4010), 712-714, 1971-11-12

    American Association for the Advancement of Science (AAAS)

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