Strontium Induced Rickets: Metabolic Basis

DOI Web Site 被引用文献4件
  • J. L. Omdahl
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
  • H. F. DeLuca
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

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<jats:p> Dietary strontium inhibits both the synthesis of 1,25-dihydroxycholecalciferol and intestinal calcium absorption in vitamin D <jats:sub>3</jats:sub> -repleted chicks. 1,25-Dihydroxycholecalciferol restores calcium absorption to normal, while 25-hydroxycholecalciferol is without effect in the strontium-fed chick. It is suggested that strontium induces rickets by blocking the biosynthesis of 1,25-dihydroxycholecalciferol, the metabolically active form of vitamin D in the intestine. </jats:p>

収録刊行物

  • Science

    Science 174 (4012), 949-951, 1971-11-26

    American Association for the Advancement of Science (AAAS)

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