Inferior Olive: Its Role in Motor Learning

DOI Web Site 被引用文献5件
  • Rodolfo Llinás
    Division of Neurobiology, University of Iowa, Oakdale 52319
  • Kerry Walton
    Division of Neurobiology, University of Iowa, Oakdale 52319
  • Dean E. Hillman
    Division of Neurobiology, University of Iowa, Oakdale 52319
  • Constantino Sotelo
    Laboratoire de Neuromorphologie, Institut National de la Santé et de la Recherche Médicale, 75014 Paris, France

抄録

<jats:p>Specific chemical lesion of the rat inferior olive by intraperitoneal administration of 3-acetylpyridine prevents recuperation from motor abnormalities generated by unilateral labyrinthine lesion. Moreover, in animals that have recuperated from the labyrinthine lesion, 3-acetylpyridine produces a reversal of the symptoms within 2 hours of administration. These results indicate that the integrity of the olivo-cerebellar system is necessary for the acquisition and retention of this form of motor learning, but that the cerebellum itself is not the seat of such learning.</jats:p>

収録刊行物

  • Science

    Science 190 (4220), 1230-1231, 1975-12-19

    American Association for the Advancement of Science (AAAS)

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