Dendritic Spine "Dysgenesis" and Mental Retardation

DOI Web Site 被引用文献17件
  • Dominick P. Purpura
    Department of Neuroscience and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461

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<jats:p>Golgi studies reveal abnormally long, thin spines and the absence of short, thick spines on dendrites of cortical neurons in retarded children with normal karyotypes. The degree of dendritic spine loss and abnormality appears to be related to age and the severity of developmental retardation. Dendritic spine "dysgenesis" is a common feature of the microstructural pathology that occurs in profound mental retardation of unknown etiology.</jats:p>

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  • Science

    Science 186 (4169), 1126-1128, 1974-12-20

    American Association for the Advancement of Science (AAAS)

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