Mechanism of Carbon Isotope Fractionation Associated with Lipid Synthesis

DOI Web Site 被引用文献38件
  • Michael J. DeNiro
    Division of Geological and Planetary Sciences, California- Institite of Technology, Pasadena 91125
  • Samuel Epstein
    Division of Geological and Planetary Sciences, California- Institite of Technology, Pasadena 91125

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<jats:p>The low carbon-13/carbon-12 ratio of lipids is shown to result from isotopic fractionation during the oxidation of pyruvate to acetyl coenzyme A. In vitro analysis of the kinetic isotope effects of this reaction indicates that there will be a large, temperature-dependent difference in the carbon-13/carbon-12 ratio between the methyl and carbonyl carbon atoms of acetyl coenzyme A and between those carbon atoms of lipid components which derive from them.</jats:p>

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  • Science

    Science 197 (4300), 261-263, 1977-07-15

    American Association for the Advancement of Science (AAAS)

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