Chloramine Mutagenesis in <i>Bacillus subtilis</i>

DOI Web Site 被引用文献5件
  • Katherine Lu Shih
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305
  • Joshua Lederberg
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305

抄録

<jats:p> Chloramine (which occurs widely as a by-product of sanitary chlorination of water supplies) is shown to be a weak mutagen, when reversion of <jats:italic>trp</jats:italic> C to <jats:italic>trp</jats:italic> <jats:sup>+</jats:sup> in <jats:italic>Bacillus subtilis</jats:italic> is used as an assay. Some DNA-repair mutants appear to be more sensitive to chloramine, suggesting the involvement of DNA targets in bactericide. The influence of plating media on survival of cells treated with chloramine suggests a bacterial repair system acting upon potentially lethal lesions induced by chloramine. </jats:p>

収録刊行物

  • Science

    Science 192 (4244), 1141-1143, 1976-06-11

    American Association for the Advancement of Science (AAAS)

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