Behavioral Fever in Newborn Rabbits

• Evelyn Satinoff

  Environmental Control Research Branch, Ames Research Center, NASA, Moffett Field, California 94035

• G. N. McEwen

  Environmental Control Research Branch, Ames Research Center, NASA, Moffett Field, California 94035

• B. A. Williams

  Environmental Control Research Branch, Ames Research Center, NASA, Moffett Field, California 94035

抄録

Rabbit pups, 12 to 72 hours old, did not develop a fever when injected intraperitoneally with a pyrogen and maintained at an ambient temperature of 32°C for 2 hours. When placed in a thermally graded alleyway, animals injected with pyrogen selected gradient positions that represented significantly higher temperatures than controls injected with saline (40.4° in contrast to 36.4°C). Allowing the pups to remain at their selected positions for 5 minutes caused a significant increase in the rectal temperatures of the pyrogen-injected pups but not that of the controls. Thus, newborn rabbits will develop a fever by behavioral means after a single injection of an exogenous pyrogen.

収録刊行物

• Science

  Science 193 (4258), 1139-1140, 1976-09-17

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363107370288219392
• NII論文ID: 30020511867
• DOI: 10.1126/science.959829
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.959829
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