Noninvasive, Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters

  • Frans F. Jöbsis
    Department of Physiology, Duke University, Durham, North Carolina 27710

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<jats:p> The relatively good transparency of biological materials in the near infrared region of the spectrum permits sufficient photon transmission through organs in situ for the monitoring of cellular events. Observations by infrared transillumination in the exposed heart and in the brain in cephalo without surgical intervention show that oxygen sufficiency for cytochrome a,a <jats:sub>3</jats:sub> , function, changes in tissue blood volume, and the average hemoglobin-oxyhemoglobin equilibrium can be recorded effectively and in continuous fashion for research and clinical purposes. The copper atom associated with heme a <jats:sub>3</jats:sub> did not respond to anoxia and may be reduced under normoxic conditions, whereas the heme-a copper was at least partially reducible. </jats:p>

収録刊行物

  • Science

    Science 198 (4323), 1264-1267, 1977-12-23

    American Association for the Advancement of Science (AAAS)

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