Dextroamphetamine: Cognitive and Behavioral Effects in Normal Prepubertal Boys

Judith L. Rapoport, Monte S. Buchsbaum, Theodore P. Zahn, Herbert Weingartner, Christy Ludlow, Edwin J. Mikkelsen

doi:10.1126/science.341313

Dextroamphetamine: Cognitive and Behavioral Effects in Normal Prepubertal Boys

DOI Web Site 被引用文献4件

Judith L. Rapoport

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014
Monte S. Buchsbaum

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014
Theodore P. Zahn

Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20014
Herbert Weingartner

Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20014
Christy Ludlow

Communicative Disorders Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014
Edwin J. Mikkelsen

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014

抄録

<jats:p>The behavioral, cognitive, and electrophysiological effects of a single dose of dextroamphetamine (0.5 milligram per kilogram of body weight) or placebo was examined in 14 normal prepubertal boys (mean age, 10 years 11 months) in a double-blind study. When amphetamine was given, the group showed a marked decrease in motor activity and reaction time and improved performance on cognitive tests. The similarity of the response observed in normal children to that reported in children with "hyperactivity" or minimal brain dysfunction casts doubt on pathophysiological models of minimal brain dysfunction which assume that children with this syndrome have a clinically specific or "paradoxical" response to stimulants.</jats:p>