Experimental Allergic Neuritis Induced by Sensitization with Galactocerebroside

• Takahiko Saida

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Kyoko Saida

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Susan H. Dorfman

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Donald H. Silberberg

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Austin J. Sumner

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Margaret C. Manning

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Robert P. Lisak

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

• Mark J. Brown

  Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104

抄録

Thirteen of 31 rabbits immunized repeatedly with bovine brain galactocerebroside developed experimental allergic neuritis, manifested by flaccid paresis and hypesthesia of four limbs, 2 to 11 months after the initial inoculation. Electrophysiological studies revealed multifocal conduction block of peripheral nerves. Perivenular demyelinative lesions associated with phagocytic mononuclear cells occurred in spinal ganglia, roots, and less frequently in distal nerves.

収録刊行物

• Science

  Science 204 (4397), 1103-1106, 1979-06-08

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1362544418853005952
• NII論文ID: 30020514903
• DOI: 10.1126/science.451555
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.451555
• データソース種別:
  • Crossref
  • CiNii Articles