Absence of Cross-Tolerance to Heroin in Morphine-Tolerant Mice

DOI Web Site 1 Citations
  • D. G. Lange
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226
  • S. C. Roerig
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226
  • J. M. Fujimoto
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226
  • R. I. H. Wang
    Department of Clinical Pharmacology, Veterans Administration Center, Wood, Wisconsin 53193

Abstract

<jats:p>Mice implanted with morphine pellets demonstrated a 30-fold increase in tolerance to subcutaneously administered morphine but showed no cross-tolerance to subcutaneously administered heroin. When given morphine intracerebroventricularly, the mice showed no tolerance to morphine or cross-tolerance to heroin. These observations depended on the presence of the morphine pellet. If the pellets were removed prior to determinations of potency, the expected responses—tolerance to morphine and cross-tolerance to heroin—were obtained. The blood-brain barrier may be a prime site for the expression of morphine tolerance in mice.</jats:p>

Journal

  • Science

    Science 208 (4439), 72-74, 1980-04-04

    American Association for the Advancement of Science (AAAS)

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