Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat

• G. P. Smith

  Cornell University Medical College and New York Hospital-Cornell Medical Center, Westchester Division, White Plains 10605

• C. Jerome

  Cornell University Medical College and New York Hospital-Cornell Medical Center, Westchester Division, White Plains 10605

• B. J. Cushin

  Cornell University Medical College and New York Hospital-Cornell Medical Center, Westchester Division, White Plains 10605

• R. Eterno

  Cornell University Medical College and New York Hospital-Cornell Medical Center, Westchester Division, White Plains 10605

• K. J. Simansky

  Cornell University Medical College and New York Hospital-Cornell Medical Center, Westchester Division, White Plains 10605

抄録

The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of body weight, intraperitoneally) after they had received bilateral lesions of the ventromedial hypothalamus or after they had undergone bilateral abdominal vagotomy or selective vagotomies. Abdominal vagotomy or gastric vagotomy abolished or reduced the satiety effect of cholecystokinin, but lesions of the ventromedial hypothalamus did not. These results demonstrate that peripherally administered cholecystokinin acts in the abdomen through gastric vagal fibers and not directly on the brain to produce satiety in the rat.

収録刊行物

• Science

  Science 213 (4511), 1036-1037, 1981-08-28

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361418518890850816
• NII論文ID: 30020520015
• DOI: 10.1126/science.7268408
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.7268408
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