Myelinated Nociceptive Afferents Account for the Hyperalgesia That Follows a Burn to the Hand

  • Richard A. Meyer
    Applied Physics Laboratory, Johns Hopkins University, Laurel, Maryland 20810
  • James N. Campbell
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205

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<jats:p>Monkeys and human subjects were exposed to a series of thermal stimuli before and after a 53°C, 30-second burn to the glabrous skin of the hand. The responses of C- and A-fiber nociceptive afferents in the monkeys and subjective responses by the humans were compared. The burn resulted in increased sensitivity of the A fibers, decreased sensitivity of the C fibers, and increased pain sensibility (hyperalgesia) in the human subjects.</jats:p>

収録刊行物

  • Science

    Science 213 (4515), 1527-1529, 1981-09-25

    American Association for the Advancement of Science (AAAS)

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