Type II Collagen Autoimmunity in Otosclerosis and Meniere's Disease

  • T. J. Yoo
    Department of Medicine, University of Tennessee Center for the Health Sciences and VA Medical Center, Memphis 38163
  • J. M. Stuart
    Department of Medicine, University of Tennessee Center for the Health Sciences and VA Medical Center, Memphis 38163
  • A. H. Kang
    Department of Medicine, University of Tennessee Center for the Health Sciences and VA Medical Center, Memphis 38163
  • A. S. Townes
    Department of Medicine, University of Tennessee Center for the Health Sciences and VA Medical Center, Memphis 38163
  • K. Tomoda
    Department of Medicine, University of Tennessee Center for the Health Sciences and VA Medical Center, Memphis 38163
  • S. Dixit
    Department of Medicine, University of Tennessee Center for the Health Sciences and VA Medical Center, Memphis 38163

抄録

<jats:p>Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.</jats:p>

収録刊行物

  • Science

    Science 217 (4565), 1153-1155, 1982-09-17

    American Association for the Advancement of Science (AAAS)

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