A Family of AMPA-Selective Glutamate Receptors

DOI Web Site 被引用文献12件
  • Kari Keinänen
    Laboratory ofMolecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 6900 Heidelberg, F.R.G.
  • William Wisden
    Laboratory ofMolecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 6900 Heidelberg, F.R.G.
  • Bernd Sommer
    Laboratory ofMolecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 6900 Heidelberg, F.R.G.
  • Pia Werner
    Laboratory ofMolecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 6900 Heidelberg, F.R.G.
  • Anne Herb
    Laboratory ofMolecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 6900 Heidelberg, F.R.G.
  • Todd A. Verdoorn
    Abteilung Zellphysiologie, Max-Planck-institut für Medizinische Forschung, 6900 Heidelberg, F.R.G.
  • Bert Sakmann
    Abteilung Zellphysiologie, Max-Planck-institut für Medizinische Forschung, 6900 Heidelberg, F.R.G.
  • Peter H. Seeburg
    Laboratory ofMolecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 6900 Heidelberg, F.R.G.

抄録

<jats:p>Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate > glutamate > kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).</jats:p>

収録刊行物

  • Science

    Science 249 (4968), 556-560, 1990-08-03

    American Association for the Advancement of Science (AAAS)

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