Depletion of CD4 <sup>+</sup> T Cells in Major Histocompatibility Complex Class II-Deficient Mice

DOI Web Site 被引用文献23件
  • Michael J. Grusby
    Department of Cancer Biology, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, MA 02115.
  • Randall S. Johnson
    Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
  • Virginia E. Papaioannou
    Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, MA 02111.
  • Laurie H. Glimcher
    Department of Cancer Biology, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, MA 02115.

抄録

<jats:p> The maturation of T cells in the thymus is dependent on the expression of major histocompatibility complex (MHC) molecules. By disruption of the MHC class II A <jats:sub>β</jats:sub> <jats:sup>b</jats:sup> gene in embryonic stem cells, mice were generated that lack cell surface expression of class II molecules. These MHC class II-deficient mice were depleted of mature CD4 <jats:sup>+</jats:sup> T cells and were deficient in cell-mediated immune responses. These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4 <jats:sup>+</jats:sup> T cells. </jats:p>

収録刊行物

  • Science

    Science 253 (5026), 1417-1420, 1991-09-20

    American Association for the Advancement of Science (AAAS)

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