Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis

• Glenn Dranoff

  Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

• Alexander D. Crawford

  Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

• Michel Sadelain

  Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

• Beverly Ream

  Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

• Asif Rashid

  Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

• Roderick T. Bronson

  Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, MA 0211 1, USA.

• G. Richard Dickersin

  Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

• Cindy J. Bachurski

  Division of Pulmonary Biology, Children's Hospital, Cincinnati, OH 45229, USA.

• Eugene L. Mark

  Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

• Jeffrey A. Whitsett

  Division of Pulmonary Biology, Children's Hospital, Cincinnati, OH 45229, USA.

• Richard C. Mulligan

  Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

抄録

The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF) was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by gene targeting techniques in embryonic stem cells. Although steady-state hematopoiesis was unimpaired in homozygous mutant animals, all animals developed the progressive accumulation of surfactant lipids and proteins in the alveolar space, the defining characteristic of the idiopathic human disorder pulmonary alveolar proteinosis. Extensive lymphoid hyperplasia associated with lung airways and blood vessels was also found, yet no infectious agents could be detected. These results demonstrate that GM-CSF is not an essential growth factor for basal hematopoiesis and reveal an unexpected, critical role for GM-CSF in pulmonary homeostasis.

収録刊行物

• Science

  Science 264 (5159), 713-716, 1994-04-29

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361418518931960064
• NII論文ID: 30020548623
• DOI: 10.1126/science.8171324
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.8171324
• データソース種別:
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  • CiNii Articles