Inhibition of NF-κB by Sodium Salicylate and Aspirin

• Elizabeth Kopp

• Sankar Ghosh

抄録

The transcription factor nuclear factor-κB (NF-κB) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-κB-dependent transcription from the Igκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.

収録刊行物

• Science

  Science 265 (5174), 956-959, 1994-08-12

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1362825893293035904
• NII論文ID: 30020549407
• DOI: 10.1126/science.8052854
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.8052854
• データソース種別:
  • Crossref
  • CiNii Articles