Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

DOI Web Site 被引用文献10件
  • Hilda Lomeli
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.
  • Johannes Mosbacher
    Max-Planck-lnstitut für Medizinische Forschung, 69120 Heidelberg, Germany.
  • Thorsten Melcher
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.
  • Thomas Höger
    BASF AG, 67056 Ludwigshafen, Germany.
  • Jörg R. P. Geiger
    Max-Planck-lnstitut für Medizinische Forschung, 69120 Heidelberg, Germany.
  • Thomas Kuner
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.
  • Hannah Monyer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.
  • Miyoko Higuchi
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.
  • Alfred Bach
    BASF AG, 67056 Ludwigshafen, Germany.
  • Peter H. Seeburg
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.

抄録

<jats:p>AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear RNA editing controls the calcium permeability of these channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain. In three of the four AMPA receptor subunits (GluR-B, -C, and -D), intronic elements determine a codon switch (AGA, arginine, to GGA, glycine) in the primary transcripts in a position termed the R/G site, which immediately precedes the alternatively spliced modules "flip" and "flop." The extent of editing at this site progresses with brain development in a manner specific for subunit and splice form, and edited channels possess faster recovery rates from desensitization.</jats:p>

収録刊行物

  • Science

    Science 266 (5191), 1709-1713, 1994-12-09

    American Association for the Advancement of Science (AAAS)

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