Similarity Among the <b> <i>Drosophila</i> </b> (6-4)Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family

DOI Web Site 被引用文献18件
  • Takeshi Todo
    T. Todo, T. Inui, H. Ayaki, M. Ikenaga, Radiation Biology Center, Kyoto University, Yoshida-konoecho, Sakyo-ku, Kyoto 606-01, Japan.
  • Haruko Ryo
    H. Ryo and T. Nomura, Department of Radiation Biology, Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565, Japan.
  • Kazuo Yamamoto
    K. Yamamoto, Department of Biology, Faculty of Science, Tohoku University, Aramaki, Aoba-ku, Sendai 980-77, Japan.
  • Hiroyuki Toh
    H. Toh, Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, Fukuoka 820, Japan.
  • Taiichiro Inui
    T. Todo, T. Inui, H. Ayaki, M. Ikenaga, Radiation Biology Center, Kyoto University, Yoshida-konoecho, Sakyo-ku, Kyoto 606-01, Japan.
  • Hitoshi Ayaki
    T. Todo, T. Inui, H. Ayaki, M. Ikenaga, Radiation Biology Center, Kyoto University, Yoshida-konoecho, Sakyo-ku, Kyoto 606-01, Japan.
  • Taisei Nomura
    H. Ryo and T. Nomura, Department of Radiation Biology, Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565, Japan.
  • Mituo Ikenaga
    T. Todo, T. Inui, H. Ayaki, M. Ikenaga, Radiation Biology Center, Kyoto University, Yoshida-konoecho, Sakyo-ku, Kyoto 606-01, Japan.

抄録

<jats:p> Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts [(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in <jats:italic>Drosophila melanogaster</jats:italic> . In the present study a gene encoding the <jats:italic>Drosophila</jats:italic> (6-4)photolyase was cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants. A homolog of the <jats:italic>Drosophila</jats:italic> (6-4)photolyase gene was also cloned from human cells. </jats:p>

収録刊行物

  • Science

    Science 272 (5258), 109-112, 1996-04-05

    American Association for the Advancement of Science (AAAS)

被引用文献 (18)*注記

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