In Vitro Antifungal Susceptibilities of <i>Trichosporon</i> Species

  • Niki I. Paphitou
    Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030
  • Luis Ostrosky-Zeichner
    Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030
  • Victor L. Paetznick
    Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030
  • Jose R. Rodriguez
    Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030
  • Enuo Chen
    Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030
  • John H. Rex
    Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030

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<jats:title>ABSTRACT</jats:title> <jats:p> The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of <jats:italic>Trichosporon</jats:italic> spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC ratios were observed for voriconazole, posaconazole, and ravuconazole, suggesting fungicidal activity. </jats:p>

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