DNA Sequence Analysis of DNA Gyrase and DNA Topoisomerase IV Quinolone Resistance-Determining Regions of <i>Salmonella enterica</i> Serovar Typhi and Serovar Paratyphi A

DOI Web Site 被引用文献4件
  • Kenji Hirose
    Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640
  • Ai Hashimoto
    Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640
  • Kazumichi Tamura
    Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640
  • Yoshiaki Kawamura
    Department of Microbiology, Gifu University, School of Medicine, 40 Tsukasa-machi, Gifu, 500-8750
  • Takayuki Ezaki
    Department of Microbiology, Gifu University, School of Medicine, 40 Tsukasa-machi, Gifu, 500-8750
  • Hiroko Sagara
    Department of Infectious Diseases, Yokohama City Hospital, 56 Okazawa-cho, Hodogaya, Yokohama City, Kanagawa, 240-8555, Japan
  • Haruo Watanabe
    Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640

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<jats:title>ABSTRACT</jats:title> <jats:p> The mutations that are responsible for fluoroquinolone resistance in the <jats:italic>gyrA</jats:italic> , <jats:italic>gyrB</jats:italic> , <jats:italic>parC</jats:italic> , and <jats:italic>parE</jats:italic> genes of <jats:italic>Salmonella enterica</jats:italic> serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the <jats:italic>gyrA</jats:italic> gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the <jats:italic>gyrB</jats:italic> , <jats:italic>parC</jats:italic> , and <jats:italic>parE</jats:italic> genes. </jats:p>

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