Roles of TolC-Dependent Multidrug Transporters of <i>Escherichia coli</i> in Resistance to β-Lactams

DOI Web Site 被引用文献21件
  • Kunihiko Nishino
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki
  • Junko Yamada
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki
  • Hidetada Hirakawa
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki
  • Takahiro Hirata
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki
  • Akihito Yamaguchi
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki

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<jats:title>ABSTRACT</jats:title> <jats:p> AcrAB exports some β-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in <jats:italic>Escherichia coli</jats:italic> cooperate with TolC. In this study, the roles of the drug exporters of <jats:italic>E. coli</jats:italic> in β-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer β-lactam antibiotic resistance, while no other drug exporters confer any β-lactam resistance even when they cooperate with TolC. </jats:p>

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