Class 1 Integron Containing Metallo-β-Lactamase Gene <i>bla</i> <sub>VIM-2</sub> in <i>Pseudomonas aeruginosa</i> Clinical Strains Isolated in Japan

DOI Web Site 4 Citations
  • Jun Yatsuyanagi
    Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874
  • Shioko Saito
    Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874
  • Seizaburo Harata
    Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874
  • Noriyuki Suzuki
    Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874
  • Yuko Ito
    Akita Kumiai General Hospital, 273-1 Iijima aza nishibukuro, Akita 011-0911
  • Ken-ichi Amano
    Central Research Laboratory
  • Katsuhiko Enomoto
    Department of Pathology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan

Abstract

<jats:title>ABSTRACT</jats:title> <jats:p> Four <jats:italic>bla</jats:italic> <jats:sub>VIM-2</jats:sub> gene-harboring <jats:italic>Pseudomonas aeruginosa</jats:italic> strains were identified. These strains possessed a class 1 integron harboring <jats:italic>ORF1</jats:italic> , <jats:italic>bla</jats:italic> <jats:sub>VIM-2</jats:sub> , and <jats:italic>aacA4</jats:italic> gene cassettes. The transposon-mediated horizontal spread of the <jats:italic>bla</jats:italic> <jats:sub>VIM-2</jats:sub> gene among these strains was suggested, which increases the threat that the <jats:italic>bla</jats:italic> <jats:sub>VIM-2</jats:sub> gene will disseminate among diverse genera of bacteria. </jats:p>

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