Virulence of Metallo-β-Lactamase-Producing <i>Pseudomonas aeruginosa</i> In Vitro and In Vivo

DOI Web Site 3 Citations
  • S. Aoki
    Department of Laboratory Medicine
  • Y. Hirakata
    Department of Laboratory Medicine
  • A. Kondoh
    Department of Laboratory Medicine
  • N. Gotoh
    Department of Microbiology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
  • K. Yanagihara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501
  • Y. Miyazaki
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501
  • K. Tomono
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501
  • Y. Yamada
    Department of Laboratory Medicine
  • S. Kohno
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501
  • S. Kamihira
    Department of Laboratory Medicine

Abstract

<jats:title>ABSTRACT</jats:title> <jats:p> We evaluated the virulence of <jats:italic>Pseudomonas aeruginosa</jats:italic> carrying <jats:italic>bla</jats:italic> <jats:sub>IMP</jats:sub> , a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia model. The presence of <jats:italic>bla</jats:italic> <jats:sub>IMP</jats:sub> did not practically change the virulence of the parent strain, and ciprofloxacin was effective against infection with <jats:italic>P. aeruginosa</jats:italic> carrying <jats:italic>bla</jats:italic> <jats:sub>IMP</jats:sub> . </jats:p>

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