Prior Infection and Passive Transfer of Neutralizing Antibody Prevent Replication of Severe Acute Respiratory Syndrome Coronavirus in the Respiratory Tract of Mice

DOI Web Site 被引用文献5件
  • Kanta Subbarao
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases
  • Josephine McAuliffe
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases
  • Leatrice Vogel
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases
  • Gary Fahle
    Microbiology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892
  • Steven Fischer
    Microbiology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892
  • Kathleen Tatti
    Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
  • Michelle Packard
    Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
  • Wun-Ju Shieh
    Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
  • Sherif Zaki
    Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
  • Brian Murphy
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases

抄録

<jats:title>ABSTRACT</jats:title><jats:p>Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 78 (7), 3572-3577, 2004-04

    American Society for Microbiology

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