Nonhepatic Cell Lines HeLa and 293 Support Efficient Replication of the Hepatitis C Virus Genotype 2a Subgenomic Replicon

DOI Web Site 被引用文献12件
  • Takanobu Kato
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo
  • Tomoko Date
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo
  • Michiko Miyamoto
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo
  • Zijiang Zhao
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo
  • Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Takaji Wakita
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo

抄録

<jats:title>ABSTRACT</jats:title> <jats:p>The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 79 (1), 592-596, 2005-01

    American Society for Microbiology

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