EndoS and SpeB from<i>Streptococcus pyogenes</i>Inhibit Immunoglobulin-Mediated Opsonophagocytosis

DOI Web Site 被引用文献2件
  • Mattias Collin
    Department of Cell and Molecular Biology, Lund University, S-221 84 Lund
  • Mikael D. Svensson
    Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden
  • Anders G. Sjöholm
    Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden
  • Jens C. Jensenius
    Department of Medical Microbiology and Immunology, University of Aarhus, DK-8000 Aarhus, Denmark
  • Ulf Sjöbring
    Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden
  • Arne Olsén
    Department of Cell and Molecular Biology, Lund University, S-221 84 Lund

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<jats:title>ABSTRACT</jats:title><jats:p>The human pathogen<jats:italic>Streptococcus pyogenes</jats:italic>primarily infects the upper respiratory tract and skin, but occasionally it disseminates and causes severe invasive disease with high mortality. This study revealed that the activity of extracellular EndoS, which hydrolyzes the functionally important N-linked oligosaccharides on opsonizing immunoglobulin G (IgG), contributes to increased survival of<jats:italic>S. pyogenes</jats:italic>in human blood ex vivo. The inability to kill the bacteria is due to reduced binding of IgG to Fc receptors and impaired classical pathway-mediated activation of complement. In addition, the activity of extracellular SpeB, which cleaves IgG into Fc and Fab fragments, also increases bacterial survival. This suggests that<jats:italic>S. pyogenes</jats:italic>expresses two enzymes, EndoS and SpeB, which modulate IgG by different mechanisms in order to evade the adaptive immune system.</jats:p>

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