Multidrug-Resistant <i>Trichosporon asahii</i> Infection of Nongranulocytopenic Patients in Three Intensive Care Units

DOI Web Site 5 Citations
  • Dana G. Wolf
    <!--label omitted: 1-->Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1;
  • Rama Falk
    <!--label omitted: 1-->Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1;
  • Moshe Hacham
    <!--label omitted: 1-->Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1;
  • Bart Theelen
    <!--label omitted: 2-->CBS Yeast Division, Utrecht, The Netherlands2;
  • Teun Boekhout
    <!--label omitted: 2-->CBS Yeast Division, Utrecht, The Netherlands2;
  • Gloria Scorzetti
    <!--label omitted: 3-->Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Key Biscayne, Florida3; and
  • Mervyn Shapiro
    <!--label omitted: 1-->Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1;
  • Colin Block
    <!--label omitted: 1-->Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1;
  • Ira F. Salkin
    <!--label omitted: 4-->Wadsworth Center, New York State Department of Health, Albany, New York4
  • Itzhack Polacheck
    <!--label omitted: 1-->Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1;

Abstract

<jats:title>ABSTRACT</jats:title> <jats:p> <jats:italic>Trichosporon asahii</jats:italic> ( <jats:italic>Trichosporon beigelii</jats:italic> ) infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. We report on the recent recovery of <jats:italic>T. asahii</jats:italic> isolates with reduced susceptibility in vitro to amphotericin B (AMB), flucytosine, and azoles from six nongranulocytopenic patients who exhibited risk factors and who developed either superficial infections (four individuals) or invasive infections (two individuals) while in intensive care units. The latter two patients responded clinically and microbiologically to AMB treatment. All six isolates were closely related according to random amplified polymorphic DNA studies and showed 71% similarity by amplified fragment length polymorphism analysis, suggesting a common nosocomial origin. We also review the literature pertaining to <jats:italic>T. asahii</jats:italic> infections and discuss the salient characteristics of this fungus and recent taxonomic proposals for the genus. </jats:p>

Journal

Citations (5)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top