Estimation of Nonlinear Elasticity Parameter of Tissues by Ultrasound

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  • Nitta Naotaka
    Institute of Information Sciences and Electronics, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan
  • Shiina Tsuyoshi
    Institute of Information Sciences and Electronics, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan

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  • Ultrasonic Electronics. Estimation of Nonlinear Elasticity Parameter of Tissues by Ultrasound.

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In this paper, a new parameter that quantifies the intensity of tissue nonlinear elasticity is introduced as the nonlinear elasticity parameter. This parameter is defined based on the empirical information that the nonlinear elastic behavior of soft tissues exhibits an exponential character. To visualize the quantitative nonlinear elasticity parameter, an ultrasonic imaging procedure involving the three-dimensional finite element method (3-D FEM) is presented. Experimental investigations that visualize the nonlinear elasticity parameter distribution of a chicken gizzard and a pig kidney embedded in a gelatin-based phantom were performed. The values extracted by ultrasound and 3-D FEM were compared with those measured by the direct mechanical compression test. Experimental results revealed that the nonlinear elasticity parameter values extracted by ultrasound and 3-D FEM exhibited good agreement with those measured by the mechanical compression test, and that the intensity of tissue nonlinear elasticity could be visualized quantitatively by the defined nonlinear elasticity parameter.

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