Healthcare Chip for Checking Health Condition from Analysis of Trace Blood Collected by Painless Needle

• Oki Akio

  Department of Materials Engineering, The University of Tokyo

• Takai Madoka

  Department of Materials Engineering, The University of Tokyo

• Ogawa Hiroki

  Department of Materials Engineering, The University of Tokyo

• Takamura Yuzuru

  Department of Materials Engineering, The University of Tokyo

• Fukasawa Takayuki

  Department of Materials Engineering, The University of Tokyo

• Kikuchi Jun

  Axiomatic Inc.

• Ito Yoshitaka

  Research & Development Center, Shindengen Kogyo Corp.

• Ichiki Takanori

  Department of Electric & Electronic Engineering, Toyo University

• Horiike Yasuhiro

  Department of Materials Engineering, The University of Tokyo

抄録

A healthcare chip for checking the health condition at home has been studied based on the analysis of a trace amount of blood collected by a painless needle. A microcapillary as the main component for the blood flow was fabricated by molding its reverse pattern made of a quartz plate on a cheap and disposable poly(ethylene terephthalate) (PET) plate with an area of 2cm×2cm. The painless needle was fabricated by polishing the tip of a stainless steel tube (SUS) with a 100 μm diameter at an angle of 10 degrees using chemical mechanical polishing (CMP) and subsequently finishing it by electropolishing. Coating the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on the inner surface of the capillary effectively suppressed the adsorption of corpuscles. A quartz electroosmosis flow pump embedded in the PET plate introduced the blood into a U-shaped capillary through the needle and the blood was centrifugally separated into the corpuscles and plasma on the chip. The plasma was then conveyed to ion-sensitive field-effect transistors (ISFETs) set on the capillary and the Na⁺ and K⁺ ion concentrations were measured with high selectivity. Finally, a series of chip operations from blood collection to measurements of the pH, Na⁺ and K⁺ ion concentrations was demonstrated.

収録刊行物

• Japanese Journal of Applied Physics

  Japanese Journal of Applied Physics 42 (6A), 3722-3727, 2003

  The Japan Society of Applied Physics

キーワード

• healthcare chip
• MPC polymer
• PET
• polyHEMA
• centrifugation
• painless needle
• electroosmosis pump
• ISFET

詳細情報

• CRID: 1390282681232023296
• NII論文ID: 10011256893
• NII論文ID: 30021839256
• NII論文ID: 130004530904
• NII論文ID: 210000053649
• NII書誌ID: AA10457675
• DOI: 10.1143/jjap.42.3722
• ISSN: 13474065
• ISSN: 00214922
• NDL書誌ID: 6570159
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6570159
• Web Site: http://stacks.iop.org/1347-4065/42/i=6R/a=3722/pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可