PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

• Thomas Lemberger

  Institut de Biologie Animale Université de Lausanne Lausanne CH-1015 Switzerland

• Béatrice Desvergne

  Institut de Biologie Animale Université de Lausanne Lausanne CH-1015 Switzerland

• Walter Wahli

  Institut de Biologie Animale Université de Lausanne Lausanne CH-1015 Switzerland

抄録

▪ Abstract  Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/thyroid/retinoic acid receptor superfamily. All their characterized target genes encode proteins that participate in lipid homeostasis. The recent finding that antidiabetic thiazolidinediones and adipogenic prostanoids are ligands of one of the PPARs reveals a novel signaling pathway that directly links these compounds to processes involved in glucose homeostasis and lipid metabolism including adipocyte differentiation. A detailed understanding of this pathway could designate PPARs as targets for the development of novel efficient treatments for several metabolic disorders.

収録刊行物

• Annual Review of Cell and Developmental Biology

  Annual Review of Cell and Developmental Biology 12 (1), 335-363, 1996-11

  Annual Reviews

キーワード

• Cell Biology
• Developmental Biology

詳細情報

• CRID: 1362262943384350848
• NII論文ID: 30022117674
• DOI: 10.1146/annurev.cellbio.12.1.335
• ISSN: 15308995
• ISSN: 10810706
• ISSN: http://id.crossref.org/issn/07434634
• Web Site: https://www.annualreviews.org/doi/pdf/10.1146/annurev.cellbio.12.1.335
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