The Molecular Diversity of Glycosaminoglycans Shapes Animal Development

DOI Web Site 被引用文献21件
  • Hannes E. Bülow
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461;
  • Oliver Hobert
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032;

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<jats:p> Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism. </jats:p>

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