The Action of Molecular Chaperones in the Early Secretory Pathway

DOI Web Site 被引用文献8件
  • Sheara W. Fewell
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;
  • Kevin J. Travers
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;
  • Jonathan S. Weissman
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;
  • Jeffrey L. Brodsky
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;

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<jats:p>▪ Abstract  The endoplasmic reticulum (ER) serves as a way-station during the biogenesis of nearly all secreted proteins, and associated with or housed within the ER are factors required to catalyze their import into the ER and facilitate their folding. To ensure that only properly folded proteins are secreted and to temper the effects of cellular stress, the ER can target aberrant proteins for degradation and/or adapt to the accumulation of misfolded proteins. Molecular chaperones play critical roles in each of these phenomena.</jats:p>

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