THE ROLE OF ANTI-INFLAMMATORY DRUGS IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE
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- John C. S. Breitner, M.D., M.P.H
- Program in Epidemiology of Dementia, Division of Geriatric Psychiatry, Duke University Medical Center, Durham, North Carolina 27710
抄録
<jats:p>▪ Abstract Risk factor intervention is a useful strategy for prevention of poorly understood diseases. Fifteen studies have examined the relation of glucocorticoid and nonsteroid antiinflammatory treatments and onset or progression of Alzheimer's disease (AD). Fourteen of these studies suggest that such treatments (especially nonsteroidal agents) prevent or ameliorate symptoms of AD. Abundant circumstantial evidence implicates inflammation in the pathogenesis of AD. Inhibition of cyclooxygenases, the central action of nonsteroidal antiinflammatory drugs (but not a prominent effect of steroids), limits inflammation, but it may also alter neural metabolic pathways, resulting in cell death from excitotoxicity or oxidative stress. Randomized controlled trials are needed to determine whether steroids, nonsteroidal antiinflammatory drugs, or both can prevent or treat the symptoms of AD.</jats:p>
収録刊行物
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- Annual Review of Medicine
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Annual Review of Medicine 47 (1), 401-411, 1996-02
Annual Reviews
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詳細情報
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- CRID
- 1360574094380935552
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- NII論文ID
- 30022132491
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- ISSN
- 1545326X
- 00664219
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- データソース種別
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- Crossref
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