Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair

DOI Web Site 被引用文献40件
  • Michael V Sofroniew
    Department of Neurobiology and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095-1763;
  • Charles L Howe
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305-5489;
  • William C Mobley
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305;

抄録

<jats:p>▪ Abstract  Nerve growth factor (NGF) was discovered 50 years ago as a molecule that promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in neural development have been characterized extensively, but recent findings point to an unexpected diversity of NGF actions and indicate that developmental effects are only one aspect of the biology of NGF. This article considers expanded roles for NGF that are associated with the dynamically regulated production of NGF and its receptors that begins in development, extends throughout adult life and aging, and involves a surprising variety of neurons, glia, and nonneural cells. Particular attention is given to a growing body of evidence that suggests that among other roles, endogenous NGF signaling subserves neuroprotective and repair functions. The analysis points to many interesting unanswered questions and to the potential for continuing research on NGF to substantially enhance our understanding of the mechanisms and treatment of neurological disorders.</jats:p>

収録刊行物

被引用文献 (40)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ