THE CARDIAC FIBROBLAST: Therapeutic Target in Myocardial Remodeling and Failure
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- R. Dale Brown
- Division of Cardiology, University of Colorado Health Sciences Center, and Denver Health Medical Center, Denver, Colorado 80262;, , ,
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- S. Kelly Ambler
- Division of Cardiology, University of Colorado Health Sciences Center, and Denver Health Medical Center, Denver, Colorado 80262;, , ,
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- M. Darren Mitchell
- Division of Cardiology, University of Colorado Health Sciences Center, and Denver Health Medical Center, Denver, Colorado 80262;, , ,
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- Carlin S. Long
- Division of Cardiology, University of Colorado Health Sciences Center, and Denver Health Medical Center, Denver, Colorado 80262;, , ,
抄録
<jats:p> ▪ Abstract Cardiac fibroblasts play a central role in the maintenance of extracellular matrix in the normal heart and as mediators of inflammatory and fibrotic myocardial remodeling in the injured and failing heart. In this review, we evaluate the cardiac fibroblast as a therapeutic target in heart disease. Unique features of cardiac fibroblast cell biology are discussed in relation to normal and pathophysiological cardiac function. The contribution of cardiac fibrosis as an independent risk factor in the outcome of heart failure is considered. Candidate drug therapies that derive benefit from actions on cardiac fibroblasts are summarized, including inhibitors of angiotensin-aldosterone systems, endothelin receptor antagonists, statins, anticytokine therapies, matrix metalloproteinase inhibitors, and novel antifibrotic/anti-inflammatory agents. These findings point the way to future challenges in cardiac fibroblast biology and pharmacotherapy. </jats:p>
収録刊行物
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- Annual Review of Pharmacology and Toxicology
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Annual Review of Pharmacology and Toxicology 45 (1), 657-687, 2005-09-22
Annual Reviews
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詳細情報 詳細情報について
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- CRID
- 1360011143736398080
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- NII論文ID
- 30022152834
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- ISSN
- 15454304
- 03621642
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- データソース種別
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