MECHANISMS OF BICARBONATE SECRETION IN THE PANCREATIC DUCT

• Martin C. Steward

  Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom;

• Hiroshi Ishiguro

  Human Nutrition and Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya 464-8601, Japan;

• R. Maynard Case

  Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom;

抄録

▪ Abstract  In many species the pancreatic duct epithelium secretes HCO 3 − ions at a concentration of around 140 mM by a mechanism that is only partially understood. We know that HCO 3 − uptake at the basolateral membrane is achieved by Na + -HCO 3 − cotransport and also by a H + -ATPase and Na + /H + exchanger operating together with carbonic anhydrase. At the apical membrane, the secretion of moderate concentrations of HCO 3 − can be explained by the parallel activity of a Cl − /HCO 3 − exchanger and a Cl − conductance, either the cystic fibrosis transmembrane conductance regulator (CFTR) or a Ca 2+ -activated Cl − channel (CaCC). However, the sustained secretion of HCO 3 − into a HCO 3 − -rich luminal fluid cannot be explained by conventional Cl − /HCO 3 − exchange. HCO 3 − efflux across the apical membrane is an electrogenic process that is facilitated by the depletion of intracellular Cl − , but it remains to be seen whether it is mediated predominantly by CFTR or by an electrogenic SLC26 anion exchanger.

収録刊行物

• Annual Review of Physiology

  Annual Review of Physiology 67 (1), 377-409, 2005-03-17

  Annual Reviews

キーワード

• Physiology

詳細情報

• CRID: 1363388845603210240
• NII論文ID: 30022155488
• DOI: 10.1146/annurev.physiol.67.031103.153247
• ISSN: 15451585
• ISSN: 00664278
• ISSN: http://id.crossref.org/issn/00664278
• Web Site: https://www.annualreviews.org/doi/pdf/10.1146/annurev.physiol.67.031103.153247
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