Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura

  • Giovanni Emilia
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Giuseppe Longo
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Mario Luppi
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Giovanna Gandini
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Monica Morselli
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Leonardo Ferrara
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Sergio Amarri
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Katia Cagossi
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
  • Giuseppe Torelli
    From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.

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<jats:title>Abstract</jats:title> <jats:p>Recent reports have suggested an association betweenHelicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pyloriinfection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 × 109/L-120 × 109/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pyloriinfection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients.</jats:p>

収録刊行物

  • Blood

    Blood 97 (3), 812-814, 2001-02-01

    American Society of Hematology

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