Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura
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- Giovanni Emilia
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Giuseppe Longo
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Mario Luppi
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Giovanna Gandini
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Monica Morselli
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Leonardo Ferrara
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Sergio Amarri
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Katia Cagossi
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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- Giuseppe Torelli
- From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy.
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<jats:title>Abstract</jats:title> <jats:p>Recent reports have suggested an association betweenHelicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pyloriinfection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 × 109/L-120 × 109/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pyloriinfection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients.</jats:p>
収録刊行物
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- Blood
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Blood 97 (3), 812-814, 2001-02-01
American Society of Hematology
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詳細情報
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- CRID
- 1361981470218523392
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- NII論文ID
- 30022492584
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- NII書誌ID
- AA00567156
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- ISSN
- 15280020
- 00064971
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