A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

DOI PDF 被引用文献6件
  • Xiao-Qiang Yan
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Ulla Sarmiento
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Yu Sun
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Guo Huang
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Jane Guo
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Todd Juan
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Gwyneth Van
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Mei-Ying Qi
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Sheila Scully
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Giorgio Senaldi
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.
  • Frederick A. Fletcher
    From the Department of Pathology/Pharmacology, Amgen, Thousand Oaks, CA.

抄録

<jats:title>Abstract</jats:title><jats:p>Notch receptors mediate cell-fate decisions through interaction with specific ligands during development. The biological role of a novel Notch ligand, Dll4, in mice was explored by reconstituting lethally irradiated mice with bone marrow (BM) cells transduced with Dll4 retroviral vector. White blood cell and lymphocyte counts in Dll4-overexpressing mice were reduced at the early stage of reconstitution but increased significantly at approximately 10 weeks after BM transplantation. BM, spleen, lymph nodes, and peripheral blood ofDll4-overexpressing mice contained predominantly CD4+CD8+ T cells and virtually lacked B cells. The Dll4-overexpressing mice eventually developed a lethal phenotype that was characterized by the progression of a T-cell lymphoproliferative disease (restricted to BM and lymphoid tissues) to transplantable monoclonal T-cell leukemia/lymphoma scattered to multiple organs. Results suggest that the interaction of Dll4with Notch1 may provide key signals for T-cell development.</jats:p>

収録刊行物

  • Blood

    Blood 98 (13), 3793-3799, 2001-12-15

    American Society of Hematology

被引用文献 (6)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ