Histone deacetylase 3 associates with and represses the transcription factor GATA-2

DOI PDF 被引用文献3件
  • Yukiyasu Ozawa
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Masayuki Towatari
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Shinobu Tsuzuki
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Fumihiko Hayakawa
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Takahiro Maeda
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Yasuhiko Miyata
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Mitsune Tanimoto
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
  • Hidehiko Saito
    From the First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.

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抄録

<jats:p>The zinc finger transcription factor GATA-2 plays a critical role in the survival and proliferation of hematopoietic stem cells. This study examined the interaction of GATA-2 with histone deacetylases (HDACs) to define the involvement of HDACs in the regulation of GATA-2 function. GATA-2 directly associates with HDAC3 but not with HDAC1. Consistent with this, HDAC3 suppressed the transcriptional potential of GATA-2, whereas HDAC1 did not affect GATA-2–dependent transcription. Results further demonstrated that GATA-2 and HDAC3 colocalized in the nucleus. These results identify GATA-2 as a nuclear target for HDAC3-mediated repression. Furthermore, GATA-2 also directly associated with HDAC5 but not with other class II HDACs examined, that is, HDAC4 and HDAC6. This is the first demonstration that a tissue-specific transcription factor directly and selectively interacts with HDAC3 and HDAC5 among HDAC family members.</jats:p>

収録刊行物

  • Blood

    Blood 98 (7), 2116-2123, 2001-10-01

    American Society of Hematology

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