OSCAR is an FcRγ-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells

DOI PDF 被引用文献4件
  • Estelle Merck
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Claude Gaillard
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Daniel M. Gorman
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Felix Montero-Julian
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Isabelle Durand
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Sandra M. Zurawski
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Christine Menetrier-Caux
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Giuseppe Carra
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Serge Lebecque
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Giorgio Trinchieri
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.
  • Elizabeth E. M. Bates
    From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy.

抄録

<jats:title>Abstract</jats:title><jats:p>We have isolated a novel cell surface molecule, the human homolog of osteoclast-associated receptor (OSCAR). Unlike mouse OSCAR, hOSCAR is widely transcribed in cells of the myeloid lineage. Notably, hOSCAR is expressed on circulating blood monocytes and CD11c+ dendritic cells but not on T and B cells. hOSCAR is continually expressed during differentiation of CD14+ monocytes into dendritic cells and maintained after maturation. hOSCAR associates with the FcRγ as shown by translocation of FcRγ to the cell surface in presence of hOSCAR and coimmunoprecipitation from transfected cell lines and ex vivo cells. Engagement of hOSCAR with specific mAb leads to Ca2+ mobilization and cytokine release, indicators of cellular activation. Endocytosis of the receptor in dendritic cells was observed, followed by passage of the internalized material into Lamp-1+ and HLA-DR+ compartments, suggesting a role in antigen uptake and presentation. Dendritic cells were able to stimulate a T-cell clone specific for an epitope of mouse IgG1 after uptake and processing of the hOSCAR-specific antibody, demonstrating the capacity of this receptor to mediate antigen presentation. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response.</jats:p>

収録刊行物

  • Blood

    Blood 104 (5), 1386-1395, 2004-09-01

    American Society of Hematology

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